973 Macrophage glycolysis-dependent IL-1β production drives keratinocyte hyperproliferation and psoriatic skin inflammation

Promotes Psoriasiform Skin Inflammation Keratinocyte Overexpression of IL-17C

Macrophage-dependent IL-1β production induces cardiac arrhythmias in diabetic mice

Diabetes mellitus (DM) encompasses a multitude of secondary disorders, including heart disease. One of the most frequent and potentially life threatening disorders of DM-induced heart disease is ventricular tachycardia (VT). Here we show that toll-like receptor 2 (TLR2) and NLRP3 inflammasome activation in cardiac macrophages mediate the production of IL-1β in DM mice. IL-1β causes prolongation...

IL-1β mediates leptin induction during inflammation.

Interleukins (IL) are key mediators of the host response to infection and inflammation. Leptin is secreted by adipose tissue and plays an important role in the control of food intake. Administration of lipopolysaccharide (LPS), tumor necrosis factor (TNF), or IL-1 acutely increases leptin mRNA and protein levels. To investigate the role of IL-1β and IL-6 in leptin expression during inflammation...

TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism

Acute lung injury (ALI) is a major component of multiple organ dysfunction syndrome (MODS) following pulmonary infection. Alveolar macrophages (AM) are at the center of the pathogenesis of the development of ALI. Interleukin-1β (IL-1β) is one of the key pro-inflammatory mediators, and its maturation is tightly controlled by the formation and activation of the inflammasome. The biological effect...

Amyloid and the Macrophage: It’s All About Local Production of IL-1β

For the past 30 years, intense effort has been directed toward understanding the molecular pathways by which cytokines, such as interleukin (IL)-1, inhibit pancreatic b-cell function and cause b-cell death. The landmark findings of the Mandrup-Poulsen and colleagues (1,2) demonstrated that IL-1, derived from conditioned media, reduces glucose-stimulated insulin secretion and causes b-cell damag...